If you have configured non-persistent optimizer statistics (a non-default configuration), InnoDB computes index cardinality values for a table the first time that table is accessed after startup, instead of storing such values in the table. This step can take significant time on systems that partition the data into many tables. Since this overhead only applies to the initial table open operation, to “warm up” a table for later use, access it immediately after startup by issuing a statement such as SELECT 1 FROM tbl_name LIMIT 1.

Optimizer statistics are persisted to disk by default, enabled by the innodb_stats_persistent configuration option. For information about persistent optimizer statistics, see Section 15.8.10.1, “Configuring Persistent Optimizer Statistics Parameters”.